New Therapy at SGPGI Slows Down Kidney Failure Progression
Combination therapy offers 2–3 years of dialysis-free relief for patients
Kumar Sanjay
With chronic kidney disease (CKD) cases on the rise, the Department of Nephrology at Sanjay Gandhi Postgraduate Institute of Medical Sciences (SGPGIMS), Lucknow, has developed a new combination therapy that has successfully delayed the need for dialysis by 2 to 3 years in more than 200 patients.
Previously, the creatinine level in patients would rise from 3 to 5 within a year. However, this therapy has been able to significantly slow down that progression. With timely intervention, patients may be able to avoid dialysis for several years.
How does the therapy work?
According to Prof. Narayan Prasad and Prof. Ravi Shankar Kushwaha from the Department of Nephrology, the therapy combines four to five key drugs:
RAS Inhibitor (Renin-Angiotensin System Inhibitor)
SGLT-2 Inhibitor (Sodium-Glucose Co-Transporter Type-2 Inhibitor)
Finerenone (Non-steroidal Mineralocorticoid Receptor Antagonist)
Semaglutide (Glucagon-like Peptide-1 Receptor Agonist)
Patients undergoing this treatment are advised to limit their protein intake to 0.8 grams per kg of body weight per day, maintain blood pressure below 130/80 mm Hg, and keep HbA1c below 7%.
The current state of the disease
Prof. Narayan Prasad noted that over 10% of India’s population is at risk of kidney disease in some form. The major risk factors include diabetes, hypertension, and high-protein diets. Kidney disease is often asymptomatic and goes undetected until it reaches an advanced stage.
Preventive measures
Test GFR (Glomerular Filtration Rate) every six months
Check protein levels in urine, especially for diabetic and hypertensive patients
Avoid protein supplements and reduce salt intake
Maintain strict control of diabetes and blood pressure
Follow a balanced diet, exercise regularly, and get periodic health checkups
> “This combination therapy offers new hope for CKD patients. With timely treatment, dialysis can be delayed for years.”
— Prof. Narayan Prasad, Head, Department of Nephrology, SGPGIMS
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